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Flow-Metabolism Coupling: The New Synthesis Roger N. Gunn GlaxoSmithKline, Greenford, Middlesex, UK |
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Flow-Metabolism Coupling: The New Synthesis Roger N. Gunn GlaxoSmithKline, Greenford, Middlesex, UK |
Quantification of receptor studies from dynamic PET data requires the application of appropriate tracer kinetic modelling techniques to derive parameters of interest, such as the binding potential which is proportional to the concentration of available receptor sites. These parameters can either be estimated by fitting bio-mathematical models at the level of anatomical regions or alternatively parametric images can be generated by considering the individual voxel time courses. Parametric images maintain the full spatial resolution of the acquired data set. However, their estimation comes at the cost of increases in both the noise in the time activity curves and the total computation time. It is therefore necessary for parametric imaging methods to be sufficiently rapid and robust to noise. The approaches that have been developed for parametric imaging may be broadly divided into model driven methods (those requiring the a priori selection of a particular compartmental model) or data driven methods (those using a generalized equation for an arbitrary tracer compartmental system). The presentation will discuss the different approaches and extensions that circumvent the need for arterial blood sampling.
Recommended
literature:
R.N. Gunn, S.R. Gunn, F.E. Turkheimer, J.A.D. Aston, and V.J. Cunningham. Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modelling. J Cereb Blood Flow Metab, 22(12):1425-1439, 2002.
R.N. Gunn, S.R. Gunn, and V.J. Cunningham. Positron emission tomography compartmental models. J Cereb Blood Flow Metab, 21(6):635-652, 2001.
R.N. Gunn, A.A. Lammertsma, S.P. Hume, and V.J. Cunningham. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage, 6(4):279-287, 1997.
V.J. Cunningham and T. Jones Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab, 13(1): 15-23, 1993.
J. Logan, J.S. Fowler, N.D. Volkow, A.P. Wolf, S.L. Dewey, D.J. Schlyer, R.R. MacGregor, R.Hitzemann, B.Bendriem, S.J. Gatley, and D.R. Christman Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab, 10(5): 740-747, 1990.