"Multireceptor mapping of the human brain with PET" Course
Sunday, June 13, Budapest Convention Centre, Room “Lehár”
Organiser: Balázs Gulyás, Karolinska Institute, Stockholm
The objective of this course is to provide the audience with a state-of-the-art overview of
(1)
the main central neuroreceptor systems in primates, with special regard to the
human brain;
(2)
the radiochemical background and in vivo imaging techniques (with special regard
to PET) used to map the central neuroreceptor systems in humans;
(3)
multiligand receptor fingerprinting of the human brain under physiological
conditions;
(4)
the changes in normal receptor fingerprints in neurological and psychiatric
diseases; and
(5) mathematical models and advanced image analysis techniques used / usable in multireceptor fingerprinting.
Course schedule
Please note the minor changes in the schedule!
|
08.00-08.15 |
Introduction Balázs Gulyás Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institute, Stockholm |
|
Session 1: |
Central neurotransmitter and neuroreceptor systems in primates Chair: Balázs Gulyás |
|
08.15-08.45 |
Neurotransmitters in the human brain Miklós Palkovits Research Group of Neuromorphology, Hungarian Academy of Sciences - Semmelweis University and National Institute of Mental Health, Bethesda |
|
08.45-09.15 |
Synaptic versus non-synaptic neurotransmission E. Sylvester Vizi, Balázs Lendvai, Balázs Rózsa Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary Tamás Roska Computer and Automation Research Institute, Hungarian Academy of Sciences, Budapest, Hungary
|
|
Session 2: |
Post mortem mapping of the major neuroreceptor systems in humans Chair: E. Sylvester Vizi |
|
09.15-09.45 |
Post mortem receptor mapping of the monkey and human brain Hĺkan Hall Department of Clinical Neuroscience, Karolinska Institute, Stockholm |
|
09.45-10.15 |
Receptor fingerprinting of cortical areas in the human brain Karl Zilles Institute of Medicine, Research Center Juelich, and C. & O. Vogt Institute of Brain Research, Heinrich-Heine University Duesseldorf, Germany |
|
10.15-10.45 |
Coffee break |
|
Session 3: |
Background to in vivo mapping of the major neuroreceptor systems in humans Chair: Karl Zilles |
|
10.45-11.15 |
Radioligands for multireceptor mapping of the human brain. I. Neuroreceptor PET radioligand development - some basics exemplified by 5-HT1A receptor radioligands Vic Pike Molecular Imaging Branch, NIMH, NIH, Bethesda |
|
11.15-11.45 |
Radioligands
for multireceptor mapping of the human brain. II. Christer Halldin Psychiatry Section, Department of Clinical Neuroscience, Karolinska Institute, Stockholm |
|
11.45-12.15 |
Roger N. Gunn GlaxoSmithKline, Greenford, Middlesex, UK |
|
12.15-12.45 |
Data-mining tools for the analysis of multireceptor data Zsolt Cselényi Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, Stockholm |
|
12.45-13.45 |
Lunch break |
|
Session 3: |
Background to in vivo mapping of the major neuroreceptor systems in humans (cont.) Chair: Miklós Palkovits |
|
13.45-14.15 |
Pharmacokinetics of binding of single ligand to multiple receptors Albert Gjedde Ĺrhus University, Ĺrhus, Denmark |
|
Session 4: |
Receptor fingerprinting of the human brain: normal situation |
|
14.15-14.45 |
Human Personality and Brain Mapping Robert Cloninger Center for Psychobiology of Personality, Washington University, St. Louis |
|
14.45-15.15 |
PET provides a link between the genetic endowment and higher brain functions Lars Farde Department of Clinical Neuroscience, Psychiatry section, Karolinska Institute and Hospital, Stockholm |
|
15.15-15.45 |
Receptor fingerprinting of the human brain in various challenge conditions with PET Balázs Gulyás Department of Neuroscience and Department of Clinical Neuroscience, Karolinska Institute, Stockholm |
|
15.45-16.15 |
Coffee break |
|
Session 5: |
Receptor fingerprinting of the human brain: neurological and psychiatric diseases Chair: Christer Halldin |
|
16.15-16.45 |
Multireceptor fingerprinting of schizophrenia Tetsuya Suhara National Institute of Radiological Sciences, Chiba |
|
16.45-17.15 |
The glial response in neurological diseases Richard Banati*, F.E. Turkheimer, L. Moran, D. Duke and M.B. Graeber *Imperial College, Hammersmith Hospital, London, UK |
|
17.15-17.30 |
General discussion. Closing remarks Balázs Gulyás |
Remark: Additional registration fee is required for this course!